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Treatment of Gastrointestinal Motility Disorders in Pregnancy
- Alan M. Nichols, MD
The Editors welcome submissions for possible publication in the Letters section. Authors of letters should:
Include no more than 300 words of text, three authors, and five references
Type with double-spacing
Send three copies of the letter, an authors' form signed by all authors, and a cover letter describing any conflicts of interest related to the contents of the letter.
Letters commenting on an Annals article will be considered if they are received within 6 weeks of the time the article was published. Only some of the letters received can be published. Published letters are edited and may be shortened; tables and figures are included only selectively. Authors will be notified that the letter has been received. If the letter is selected for publication, the author will be notified about 3 weeks before the publication date. Unpublished letters cannot be returned.
Annals welcomes electronically submitted letters.
TO THE EDITOR:
Baron and colleagues [1] state that sucralfate (Carafate) appears to be safe (in pregnancy) because none of the drug is absorbed. Although the therapeutic action of the drug is believed to be topical, 0.5% to 2.2% of ingested sucralfate is excreted in the urine. Given that a standard dose of sucralfate is 1 g, even these small percentages result in a significant amount of circulating drug. At the highest ranges, the amount of sucralfate in circulation could exceed the total therapeutic dose of other agents such as famotidine (20 mg). Sucralfate may well be safe in pregnancy, but lack of adverse effects cannot be assumed solely on the basis of poor absorption [2].
Alan M. Nichols
The Editors welcome submissions for possible publication in the Letters section. Authors of letters should:
Include no more than 300 words of text, three authors, and five references
Type with double-spacing
Send three copies of the letter, an authors' form signed by all authors, and a cover letter describing any conflicts of interest related to the contents of the letter.
Letters commenting on an Annals article will be considered if they are received within 6 weeks of the time the article was published. Only some of the letters received can be published. Published letters are edited and may be shortened; tables and figures are included only selectively. Authors will be notified that the letter has been received. If the letter is selected for publication, the author will be notified about 3 weeks before the publication date. Unpublished letters cannot be returned.
Annals welcomes electronically submitted letters.
- Copyright 2004 by the American College of Physicians
