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Serum Cytokines and the Eosinophilia Myalgia Syndrome
- Daniel J. Clauw, MD;
- Leila H. Zackrison, MD; and
- Paul Katz, MD
Excerpt
To the Editors: Varga and colleagues (1) outline many of the recent advances in our understanding of the eosinophilia myalgia syndrome (EMS). Current theories about the pathogenesis of this disease include direct toxic effects from both eosinophil products and tryptophan metabolites as well as effects mediated by activated T cells, monocytes, and fibroblasts.
Because serum cytokine elevation is known to be related to an activated immune system, we compared the levels of serum cytokines with clinical disease activity in patients with EMS. Sixty-eight serum samples from twenty patients fulfilling the Centers for Disease Control (CDC) criteria for the diagnosis of
This 100-word excerpt has been provided in the absence of an abstract.
