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Hepatitis B in Patients with HIV Infection: Relationship to AIDS and Patient Survival
- Bruce F. Scharschmidt, MD;
- Michael J. Held, MA;
- Harry H. Hollander, MD;
- Alexandra E. Read, MD;
- Joel E. Lavine, MD, PhD;
- Genevieve Veereman, MD;
- Richard F. McGuire, MD; and
- M. Michael Thaler, MD
Excerpt
Hepatitis B virus (HBV) infection is common among persons with human immunodeficiency virus (HIV) infection (1-4). Hepatitis B virus DNA is found in lymphoid cells of patients co-infected with HBV and HIV (5), and studies in cultured cells co-infected or transfected with HIV and HBV DNA indicate that the HBV X gene product enhances HIV gene expression (6, 7). These findings suggest that infection with HBV may accelerate progression of HIV-related disease, but limited clinical information is available. Therefore, we retrospectively analyzed sera from 511 HIV-infected patients for evidence of hepatitis B, in order to examine the relationship between serologic
This 100-word excerpt has been provided in the absence of an abstract.
Acknowledgments
Acknowledgments: The authors thank Drs. Jim Carlson, Peter Bacchetti, David W. Feigal, Jr., John Greenspan, Don Ganem, Steven Lidofsky, Marvin Sleisenger, and Teresa Wright for their advice and help. They also thank Ms. Sandra Sciford and Ms. Sadie McFarland for preparation of the manuscript.
Article and Author Information
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From the University of California, San Francisco, California. For current author addresses, see end of text.
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Grant Support: By a grant from the UCSF AIDS Clinical Research Center with monies allocated by the State of California University-Wide AIDS Research Program, a State of California University-Wide Research Program grant (MMT-R90SF225), an American Liver Foundation Research Scholar Award, and the UCSF Liver Center (AM 26740).
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Requests for Reprints: B. F. Scharschmidt, MD, 1120 HSW, Gastroenterology Division, University of California, San Francisco, CA 94143-0538.
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Current Author Addresses: Dr. Scharschmidt, 1120 HSW, Gastroenterology Division, University of California, San Francisco, CA 94143-0538.
Mr. Held: Journal of Clinical Investigation Editorial Office, University of California, San Diego, P.O. Box 85182, San Diego, CA 92186-5112.
Dr. Hollander: Department of Medicine and Stomatology, University of California, San Francisco, Room A555, Box 0210, San Francisco, CA 94143.
Dr. Read: Overlake Internal Medicine Associates, 1011 116th Avenue, N.E., Bellevue, WA 98004.
Dr. Lavine: Children's Hospital, 320 Longwood Avenue, ENDERS 4, Boston, MA 02115.
Dr. Veereman: University Hospital of Leuven, B-3000 Leuven, Belgium.
Dr. McGuire: Internal Medicine Specialists Medical Group, Inc., 400 W. Central Avenue, Suite 206, Brea, CA 92621.
Dr. Thaler: Department of Pediatrics, Division of Gastroenterology and Nutrition, Room M-680, University of California, San Francisco, CA 94143.
