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Graft-versus-Host Disease in a Liver Transplant Recipient
- Robert H. Collins, Jr., MD;
- Barry Cooper, MD;
- Afzal Nikaein, PhD;
- Goran Klintmalm, MD, PhD; and
- Joseph W. Fay, MD
Excerpt
The classic requirements for graft-versus-host disease (GVHD) (1) exist in recipients of liver allografts: 1) The donor liver and recipient are histo-incompatible; 2) lymphocytes within the lymph nodes and lymphatics of the donor graft are capable of recognizing the recipient as foreign and reacting to the recipient (for example, hemolysis of ABO-incompatible erythrocytes by allograft-derived antibodies has been well described [2]); and 3) the recipient is receiving post-transplant immunosuppressive therapy that could conceivably prevent recipient immune cells from eliminating anti-recipient donor cells.
Despite the presence of immunosuppression, GVHD is believed to be a rare phenomenon in liver transplant patients; few
This 100-word excerpt has been provided in the absence of an abstract.
Acknowledgments
Acknowledgment: The authors thank Betty Webb for preparation of the manuscript.
Article and Author Information
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From Baylor University Medical Center, Dallas, Texas. For current author addresses, see end of text.
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Grant Support: By the Delta Delta Delta Sorority Fund.
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Requests for Reprints: Robert H. Collins, Jr., MD, Bone Marrow Transplantation Research, Baylor University Medical Center, Dallas, TX 75246.
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Current Author Addresses: Drs. Collins and Fay: Bone Marrow Transplantation Research, Baylor University Medical Center, Dallas, TX 75246.
Dr. Cooper: 3320 Live Oak, #600, Dallas, TX 75204.
Dr. Nikaein: Transplant Immunology, Baylor University Medical Center, Dallas, TX 75246.
Dr. Klintmalm: Transplant Surgery, Baylor University Medical Center, Dallas, TX 75246.
