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Immunoglobulin A (IgA) Immune Complex Pneumonitis in a Patient with IgA Nephropathy
- Russell W. Harland, MD;
- Carl G. Becker, MD;
- James C. Brandes, MD;
- Claire Fritsche, MD; and
- David Y. Rosenzweig, MD
Excerpt
Idiopathic immunoglobulin A (IgA) nephropathy (Berger disease) is a syndrome characterized by mesangial proliferative glomerulonephritis with prominent mesangial deposits of IgA (1, 2). Clinical features of this syndrome include a prolonged course of persistent microscopic hematuria, intermittent macroscopic hematuria, and variable proteinuria. Typically, episodes of gross hematuria are preceded by gastroenteritis (3) or pulmonary symptoms (1, 2). Deposition of IgA in areas other than the kidney and skin has not been well described. It has been estimated that between 10% and 20% of patients progress to end-stage renal failure (1, 2).
Although the pathogenesis of IgA nephropathy is unclear, most investigators
Acknowledgments
Acknowledgment: The authors thank Susan M. Zirbel for assistance in preparation of the manuscript.
Article and Author Information
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From the Medical College of Wisconsin, Milwaukee, Wisconsin. For current author addresses, see end of text.
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Requests for Reprints: David Y. Rosenzweig, MD, Division of Pulmonary and Critical Care Medicine, Milwaukee County Medical Complex, 8700 West Wisconsin Avenue, Milwaukee, WI 53226.
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Current Author Addresses: Drs. Harland and Rosenzweig: Division of Pulmonary and Critical Care Medicine, Milwaukee County Medical Complex, 8700 West Wisconsin Avenue, Milwaukee, WI 53226.
Dr. Becker: Department of Pathology, Milwaukee County Medical Complex, 8700 West Wisconsin Avenue, Milwaukee, WI 53226.
Drs. Brandes and Fritsche: Nephrology Division, Froedtert Memorial Lutheran Hospital, 9200 West Wisconsin Avenue, Milwaukee, WI 53226.
