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Insulin-like Growth Factors in Health and Disease
- Derek LeRoith, MD, PhD;
- David Clemmons, MD;
- Peter Nissley, MD; and
- Matthew M. Rechler, MD
Abstract
▪ The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are ubiquitous and important for normal human growth and development. Modern techniques including specific radioimmunoassays, radioreceptor assays and recombinant DNA technology have improved our understanding of the role of IGFs in growth and development. In addition to enhancing our understanding of normal physiology, these techniques assess changes in these hormones, binding proteins, and receptors in pathologic conditions including growth retardation, acromegaly, malnutrition, diabetes, and malignancy. Further, these studies have led to improvement in the assessment of responses to certain therapies used in the treatment of these diseases and may lead to improvements in these therapies.
Article and Author Information
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An edited summary of a Clinical Staff Conference held 30 January 1991 in the Amphitheater, Building 10, National Institutes of Health, Bethesda, Maryland. The conference was sponsored by the National Istitute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health.
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Authors who wish to cite a section of the conference and specifically indicate its author may use this example for the form of reference:
Nissley P. Insulin-like growth factor receptors, pp. 856-857. In: LeRoith D, moderator. Insulin-like growth factors in health and disease. Ann Intern Med. 1992;116:854-862.
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Requests for Reprints: Derek LeRoith, MD, PhD, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Room 8S423, National Institutes of Health, Building 10, Bethesda, MD 20892.
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Current Author Addresses: Drs. LeRoith and Rechler: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Bethesda, MD 20892.
Dr. Nissley: National Cancer Institute, National Institutes of Health, Building 10, Bethesda, MD 20892.
Dr. Clemmons: Division of Endocrinology, University of North Carolina, Chapel Hill, NC 27599.
