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Diabetes Mellitus Induced by Megestrol Acetate in a Patient with AIDS and Cachexia
- Keith Henry, MD;
- Scott Rathgaber, MD;
- Christopher Sullivan, MD; and
- Kathleen McCabe, RN
Excerpt
Megestrol acetate has been reported to be a relatively nontoxic drug (1, 2) that is efficacious in the treatment of cachexia associated with the acquired immune deficiency syndrome (AIDS) (3). We report the case of a patient with AIDS who developed diabetes mellitus requiring insulin therapy 13 weeks after beginning megestrol therapy and who experienced an exacerbation of his diabetes when rechallenged with megestrol.
Case Report A 46-year-old man had been diagnosed with AIDS 2.5 years earlier when a skin biopsy specimen showed Kaposi sarcoma. His treatment regimen is summarized in Figure 1. Before beginning therapy with megestrol acetate, his
Article and Author Information
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From St. Paul-Ramsey Medical Center, St. Paul, Minnesota. For current author addresses, see end of text.
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Requests for Reprints: Keith Henry, MD, HIV/AIDS Programs, Suite 125, St. Paul-Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101.
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Current Author Addresses: Drs. Henry and Sullivan, and Ms. McCabe: HIV/AIDS Programs, Suite 125, St. Paul-Ramsey Medical Center, 640 Jackson Street. St. Paul. MN 55101.
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Dr. Rathgaber: Department of Gastroenterology, Room 2300, University of Indiana Hospital, 1926 West Michigan Avenue, Indianapolis, IN 46202.
