Histamine-2 Receptor Blockers and Delirium

Excerpt

To the editors: I read with interest the article by Cantu and Korek (1) in which they reviewed the literature on central nervous system reactions to histamine-2 receptor (H₂) blockers. As the chief of a psychiatry consultation service in a university teaching hospital, I have seen at least five cases of delirium (as defined by the DSM-II-R [2]) associated with H2 blocker use. In all five cases, however, the medication was being given intravenously. Thus, I was surprised that the authors did not address the route of administration in their discussion of risk factors. A MEDLINE literature search yielded no