The Eosinophilia-Myalgia Syndrome and the Brain

Excerpt

To the Editors: We report the cases of two patients with the eosinophilia-myalgia syndrome and currently normal eosinophil counts who show progressive central nervous system problems and abnormal magnetic resonance imaging (MRI) scans.

Late in 1989, both patients had a diagnosis of the eosinophilia-myalgia syndrome fulfilling criteria of the Centers for Disease Control (1). Both patients were treated with corticosteroids and have had normal eosinophil counts for at least 15 months. Symptoms and signs suggestive of central nervous system disease have appeared in the last 7 months, with clinical evidence of slow progression. In Patient 1, MRI scans done 15