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Colon Polyps in Acromegaly
- Shereen Ezzat, MD;
- Carey Strom, MD; and
- Shlomo Melmed, MD
Excerpt
Acromegaly results from unrestrained secretion of growth hormone and insulin-like growth factor 1 (IGF-1), usually occurring as a result of a pituitary somatotroph adenoma (1). Of 283 acromegalic patients retrospectively examined, 13 have been reported to have adenocarcinoma of the colon (2). Klein and associates (3) screened 17 patients with acromegaly for colonic lesions. Nine patients were identified with polyps, 5 of whom had adenomatous lesions. These results prompted us to prospectively examine the association of colonic polyps and acromegaly in patients with hypersomatotropism with no other identifiable risk factors for colon neoplasia. We chose complete colonoscopy as our screening
This 100-word excerpt has been provided in the absence of an abstract.
Article and Author Information
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From Cedars-Sinai Medical Center-UCLA School of Medicine, Los Angeles, California. For current author addresses, see end of text.
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Grant Support: By National Institutes of Health grants DK 34824 and DK 41906.
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Requests for Reprints: Shlomo Melmed, MD, Division of Endocrinology and Metabolism, Cedars-Sinai Medical Center, B-131, 8700 Beverly Boulevard, Los Angeles, CA 90048.
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Current Author Addresses: Drs. Ezzat and Melmed: Division of Endocrinology and Metabolism, Cedars-Sinai Medical Center, B-131, 8700 Beverly Boulevard, Los Angeles, CA 90048.
Dr. Strom: 8635 West 3rd Street, 970 W., Los Angeles, CA 90048.
