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Mycosis Fungoides Arthropathy
- Robert G. Berger, MD;
- Susan J. Knox, MD, PhD;
- Ronald Levy, MD;
- Jeffrey L. Sklar, MD, PhD;
- Philip Cohen, MD; and
- Thomas Reichert, MD, PhD
Excerpt
We report the case of a patient with mycosis fungoides who developed a progressive arthropathy from malignant synovial infiltration. The arthropathy responded to treatment with a chimeric, human-murine monoclonal antibody against T-helper cells.
Case Report At 39 years of age, this previously healthy woman developed a rash over her abdomen and, subsequently, over her thighs and arms. The rash was characterized by hyperkeratotic, erythematous plaques. Two years later, she developed a symmetric, nonerosive small hand-joint arthritis. Tests for rheumatoid factor and antinuclear antibody had negative results.
Over the next year, the patient's rheumatic and cutaneous symptoms responded to neither hydroxychloroquine
Article and Author Information
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From the University of North Carolina School of Medicine, Chapel Hill, North Carolina; Stanford University School of Medicine, Stanford California; Becton-Dickinson, Mountain View, California; and Harvard Medical School, Boston, Massachusetts.
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Requests for Reprints: Robert G. Berger, MD, Division of Rheumatology & Immunology, University of North Carolina, Chapel Hill School of Medicine, Campus Box 7280, Chapel Hill, NC 27599-7280.
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Current Author Addresses: Drs. Berger and Cohen: Division of Rheumatology & Immunology, University of North Carolina, Chapel Hill School of Medicine, Campus Box 7280, Chapel Hill, NC 27599-7280.
Drs. Knox and Levy: Department of Radiation Oncology, Stanford University Hospital, Stanford, CA 94305.
Dr. Sklar: Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115.
Dr. Reichert: Becton-Dickinson, One Becton Drive, Franklin Lakes, NJ 07417.
