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Immunogenicity of an Inactivated Hepatitis A Vaccine
- Maria H. Sjogren, MD, MPH;
- Charles H. Hoke, MD;
- Leonard N. Binn, PhD;
- Kenneth H. Eckels, PhD;
- Doria R. Dubois, PhD;
- Lionel Lyde;
- Amy Tsuchida, MD;
- Stanley Oaks, Jr., PhD;
- Ruth Marchwicki, BS;
- Wayne Lednar, MD, PhD;
- Robert Chloupek, MD;
- John Ticehurst, MD; and
- William H. Bancroft, MD
Excerpt
Although hepatitis A is a disease without chronic sequelae, it is associated with serious morbidity in adults. An inactivated hepatitis A vaccine prepared at the Walter Reed Army Institute of Research was observed to successfully immunize owl monkeys (1). In a preliminary study, this vaccine was given to eight men, all of whom developed neutralizing antibody to hepatitis A virus (anti-HAV) (2). The present study was designed to confirm the vaccine's immunogenicity, to obtain additional evidence of vaccine safety, and to establish a practical dosing schedule.
Methods Forty-two male volunteers, 18 to 50 years of age, were enrolled from among
Note in Proof
The opinions contained herein are those of the authors and should not be construed as representing those of the Department of the Army or Department of Defense.
Acknowledgments
Acknowledgments: The authors thank Sergeant Richard Lewis and Major Keith Shafer for assistance in conducting the study and Robert Burge for statistical analysis.
Article and Author Information
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From Walter Reed Army Institute of Research, Washington, D.C.; Fort Lewis, Washington; and United States Army Medical Materiel Development Activity, Frederick, Maryland. For current author addresses, see end of text.
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Requests for Reprints: Maria H. Sjogren, MD, MPH, Department of Virus Diseases, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100.
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Current Author Addresses: Drs. Sjogren, Hoke, Binn, Eckels, Dubois, and Ticehurst, Mr. Lyde, and Ms. Marchwicki: Walter Reed Army Institute of Research, Washington, D.C. 20307-5100.
Dr. Tsuchida: Department of Gastroenterology, Fort Lewis, WA 98433.
Dr. Oaks: Institute of Medicine, National Academy of Sciences, 2101 Constitution Avenue, NW, Washington, D.C. 20418.
Dr. Lednar: Building 320, Eastman-Kodak, Kodak Park Company, Rochester, NY 14652-3615.
Dr. Chloupek: HQ, Forces Command (FCMD), Fort McPherson, GA 30330-6000.
Dr. Bancroft: HQ, VSAMRDC, SGRD-PLA, Fort Detrick, Frederick, MD 21702-5012.
