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Life-Threatening Diarrhea after Short-Term Misoprostol Use in a Patient with Crohn Ileocolitis
- Asher Kornbluth, MD;
- Rakesh Gupta, MD; and
- Charles D. Gerson, MD
Excerpt
Misoprostol, a prostaglandin E analog, was recently approved for use in the prevention of nonsteroidal anti-inflammatory drug-induced ulcer disease. Its commonest side effects, diarrhea and abdominal cramping (1), may be attributable to the ability of prostaglandin E to stimulate small-bowel secretion (2) and motility (3). In patients with inflammatory bowel disease, prostaglandin E2 levels are elevated and such elevations may play a role in causing intestinal inflammation and diarrhea (4). We report the case of a patient with unrecognized Crohn ileocolitis who developed a nearly fatal secretory diarrhea after short-term use of misoprostol.
Case Report A 56-year-old woman was admitted
This 100-word excerpt has been provided in the absence of an abstract.
Acknowledgments
Acknowledgment: The authors thank Marguerite Pizzati for manuscript preparation.
Article and Author Information
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From the Mount Sinai Medical Center, New York, New York. For current author addresses, see end of text.
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Requests for Reprints: Asher Kornbluth, MD, Division of Gastroenterology, Box 1069, The Mount Sinai Medical Center, One Gustave L. Levy Place, New York, NY 10029.
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Current Author Addresses: Drs. Kornbluth, Gupta, and Gerson: The Mount Sinai Medical Center, Division of Gastroenterology, Box 1069, One Gustave L. Levy Place, New York, NY 10029.
