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Severe Acetaminophen Toxicity in a Patient Receiving Isoniazid
- Rosanne Murphy, MD;
- Richard Swartz, MD; and
- Paul B. Watkins, MD
Excerpt
A woman who was being treated with isoniazid developed life-threatening hepatic and renal toxicity after ingesting not more than 11.5 g of acetaminophen. We believe the toxicity may have resulted from a previously unrecognized interaction between isoniazid and acetaminophen and propose a molecular basis for this interaction.
Case Report A previously healthy 19-year-old woman ingested a handful of acetaminophen tablets in a suicide gesture after a domestic dispute that occurred at 22:30 hours. The patient awoke the following morning at 06:00 hours with sharp abdominal pain, nausea, and vomiting, and was taken to the nearest hospital emergency room. The bottle
Article and Author Information
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From the University of Michigan Medical Center, Ann Arbor, Michigan. For current author addresses, see end of text.
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Requests for Reprints: Paul B. Watkins, MD, 6520 MSRB I, Box 0682, University of Michigan Medical Center, 1150 West Medical Center Drive, Ann Arbor, MI 48109.
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Current Author Addresses: Dr. Murphy: 3912 Taubman Center, Box 0362, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109.
Dr. Swartz: 3914 Taubman Center, Box 0364, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109.
Dr. Watkins: 6520 MSRB I, Box 0682, University of Michigan Medical Center, 1150 West Medical Center Drive, Ann Arbor, MI 48109.
