Adverse Effects of Nonsteroidal Anti-inflammatory Drugs on Renal Function
- Michael D. Murray, PharmD; and
- D. Craig Brater, MD
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Purdue University School of Pharmacy and
Pharmacal Sciences
West Lafayette, IN 47907 -
Indiana University School of Medicine
Indianapolis, IN 46223
Excerpt
A number of clinical conditions, including congestive heart failure, cirrhosis, and renal insufficiency, require local synthesis of vasodilating prostaglandins to maintain renal perfusion (for review, see 1-3). When patients with these disorders receive nonsteroidal anti-inflammatory drugs (NSAIDs), they are at risk for an acute ischemic insult to the kidney because inhibition of these prostaglandins allows unopposed vasoconstriction to occur. Numerous interventional (as opposed to epidemiologic) studies have been done that incorporate study designs generally similar to that reported by Whelton and colleagues in this issue (4). The collective results of such studies show that a large proportion of patients preselected
This 100-word excerpt has been provided in the absence of an abstract.
Article and Author Information
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Requests for Reprints: D. Craig Brater, MD, Wishard Memorial Hospital, Clinical Pharmacology Division, 1001 West 10th Street, OPW 320, Indianapolis, IN 46202.
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