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Oculo-Facial-Skeletal Myorhythmia in Whipple Disease: Treatment with Ceftriaxone
- Charles H. Adler, MD, PhD; and
- Steven L. Galetta, MD
Excerpt
Whipple disease is a chronic, systemic disorder resulting in steatorrhea, weight loss, arthralgias, fever, and neurologic symptoms (1). Central nervous system manifestations may occur without systemic involvement (2-4), and include headache, seizures, meningitis, myoclonus, dementia, and supranuclear ophthalmoplegia (1-4). A unique, possibly pathognomonic, movement disorder, involving a slow (1 Hz) convergent-divergent pendular nystagmus, associated with synchronous, rhythmic movements of the mouth and other body parts, has been called oculomasticatory or oculo-facial-skeletal myorhythmia. It has previously been reported in six patients with biopsy-proven Whipple disease (5-9). We report a patient with Whipple disease with amnesia, meningitis, supranuclear ophthalmoparesis, and oculo-facial-skeletal myorhythmia
This 100-word excerpt has been provided in the absence of an abstract.
Article and Author Information
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From the Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. For current author addresses, see end of text.
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Requests for Reprints: Steven L. Galetta, MD, Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283.
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Current Author Addresses: Drs. Adler and Galetta: Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283.
