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Extracorporeal Photochemotherapy for Drug-Resistant Pemphigus Vulgaris
- Alain H. Rook, MD;
- Brian V. Jegasothy, MD;
- Peter Heald, MD;
- George T. Nahass, MD;
- Chérie Ditre, MD;
- William K. Witmer, BS;
- Gerald S. Lazarus, MD; and
- Richard L. Edelson, MD
Excerpt
The extracorporeal exposure of pathogenic peripheral blood leukocytes to the natural compound 8-methoxypsoralen (8-MOP) and ultraviolet A radiation has provided great benefit in certain advanced forms of cutaneous T-cell lymphoma (1). Extracorporeal photochemotherapy was given to four patients with persistent cases of the autoimmune blistering disease, pemphigus vulgaris, who had previously needed large doses of immunosuppressive drugs to control their disabling disease. Two representative cases are described in detail.
Case Reports Patient 1
A 61-year-old man who had extensive blisters and erosions that had been resistant to many months of prednisone and azathioprine therapy had extracorporeal photochemotherapy initiated with treatments
This 100-word excerpt has been provided in the absence of an abstract.
Article and Author Information
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From the Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; and Yale University School of Medicine, New Haven, Connecticut. For current author addresses, see end of text.
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Grant Support: Supported in part by grant MO1RR00040-29 from the National Institutes of Health.
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Requests for Reprints: Alain H. Rook, MD, Department of Dermatology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104.
