The Acquired Immunodeficiency Syndrome (AIDS) Dementia Complex
- David D. Ho, MD;
- Dale E. Bredesen, MD;
- Harry V. Vinters, MD; and
- Eric S. Daar, MD
Abstract
The acquired immunodeficiency syndrome (AIDS) dementia complex is a frequent and devastating complication of infection with human immunodeficiency virus-type 1 (HIV-1). Features of the AIDS dementia complex include decreased memory, the inability to concentrate, apathy, and psychomotor retardation. Typical neuropathologic findings include gliosis, focal necrosis of neurons, perivascular inflammation, formation of microglial nodules, multinucleated giant cells, and demyelination. That HIV-1 is the direct cause of this neurologic syndrome is strongly supported by the available evidence. In addition, several studies have identified the monocyte-macrophage as the predominant cell type in the brain infected with HIV-1. However, the mechanisms by which the infected monocytes-macrophages mediate neurologic dysfunction and destruction nave not been elucidated.
Article and Author Information
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An edited summary of an Interdepartmental Conference arranged by the Department of Medicine of the UCLA School of Medicine, Los Angeles, California. William M. Pardridge, MD, Professor of Medicine, is Director of Conferences.
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Authors who wish to cite a section of the conference and specifically indicate its author can use this example as the form of the reference:
Bredesen, DE. Clinical features, pp 400-402. In: Ho DD, moderator. The acquired immunodeficiency syndrome (AIDS) dementia complex. Ann Intern Med. 1989;111:400-410.
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Grant Support: Supported in part by grants AI25542 and AI28747 from the National Institutes of Health; grants R87CS002, R87CS003, and R88CS008 from the University of California Task Force on AIDS; grant NS26312 from the National Institute of Nervous and Communicative Disorders and Stroke; and a gift from the Friar's Charity Club Foundation.
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Requests for Reprints: David D. Ho, MD, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048.
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Current Author Addresses: Drs. Ho and Daar: Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048.
Dr. Bredesen: UCLA Medical Center, Department of Neurology, 710 West wood Plaza, Los Angeles, CA 90024-1769.
Dr. Vinters: UCLA Medical Center, Department of Pathology, Room 18-170 NPI, Los Angeles, CA 90024-1732.
- ©1989 American College of Physicians
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