RSS Feeds
Selective Vulnerability of the Brain: New Insights into the Pathophysiology of Stroke
- Robert C. Collins, MD;
- Bruce H. Dobkin, MD; and
- Dennis W. Choi, MD, PhD
Excerpt
Stroke is a major cause of morbidity and mortality in the United States with 250 000 cases per year. Cerebral ischemia is the largest category of stroke with cardiac arrest, profound hypotension, and vascular occlusion the principal causes. Traditional approaches to the treatment of ischemic stroke focus on maintaining cardiac output, blood pressure, cerebral blood flow, and on preventing thrombosis. Recently, attention has been focused on developing new therapies that are directed toward abnormal biochemical events at excitatory synapses. Ischemia causes impairment of brain energy metabolism and the release of excessive amounts of glutamate into the extracellular space. This process
Acknowledgments
Acknowledgments: The authors thank Annette V. Terzian, UCLA School of Medicine, for editorial assistance.
Article and Author Information
-
An edited summary of an Interdepartmental Conference arranged by the Department of Medicine of the UCLA School of Medicine, Los Angeles, California. William M. Pardridge, MD, Professor of Medicine, is Director of Conferences.
-
Authors who wish to cite a section of the conference and specifically indicate its author can use this example as the form of the reference:
Choi DW. Toward a new pharmacology of ischemic neuronal death, pp 996-999. In: Collins RC, moderator. Selective vulnerability of the brain: new insights into the pathophysiology of stroke. Ann Intern Med. 1989;110:992-1000.
-
Grant Support: Supported in part by grants TJSPHS 14834 and NIH NS21628.
-
Requests for Reprints: Robert C. Collins, MD, Reed Neurological Research Center, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90024.
-
Current Author Addresses: Drs. Collins and Dobkin: UCLA School of Medicine, Department of Neurology, 710 Westwood Plaza, Los Angeles, CA 90024.
Dr. Choi: Stanford University School of Medicine, Department of Neurology, Stanford, CA 94305.
- © 1989 American College of Physicians
