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Carboplatin and Renal Function
- Egbert F. Smit, MD;
- Dirk Th. Sleijfer, MD;
- Sijtze Meijer, MD;
- Nanno H. Mulder; and
- Pieter E. Postmus, MD
Excerpt
To the Editor: Reed and Jacob (1) report on renal toxicity following high-dose carboplatin (800 mg/m2 body surface) in patients pretreated with cisplatin who have refractory ovarian cancer. A substantial decrease in creatinine clearance was seen in three patients. In nine other patients who received vigorous intravenous hydration no reductions in creatinine clearance occurred. Mulder and colleagues (2) reported a case history of a patient who developed renal failure after a cumulative dose of carboplatin of 750 mg/m2 in 3 days. This patient was also pretreated with a regimen containing cisplatin. However, carboplatin has also proved to be nephrotoxic
This 100-word excerpt has been provided in the absence of an abstract.
