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Coronary Morbidity and Mortality, Pre-existing Silent Coronary Artery Disease, and Mild Hypertension
- Brian F. O'Kelly, MB;
- Barry M. Massie, MD;
- Julio F. Tubau, MD; and
- Jadwiga Szlachcic, MD
Excerpt
Experimental findings in animals and epidemiologic studies in humans provide strong evidence that hypertension promotes the onset and progression of atherosclerosis. However, effective antihypertensive therapy has not consistently reduced the incidence of cardiac events in the major trials of treatment for mild hypertension. In reviewing these trials and the recent data on the pathophysiologic interrelationships among hypertension, atherosclerosis, and myocardial ischemia, two factors stand out: First, the power of these trials to produce a positive result was limited because of their size, entry criteria, duration, and other considerations; second, autopsy and epidemiologic data suggest that some patients in these trials
Article and Author Information
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From the University of California, San Francisco, and San Francisco Veterans Administration Center, San Francisco, California. For current author addresses, see end of text.
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Grant Support: Supported in part by the Veterans Administration Research Service and the Alberta Heritage Foundation for Medical Research.
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Requests for Reprints: Barry M. Massie, MD, Cardiology Division (111C), Veterans Administration Medical Center, 4150 Clement Street, San Francisco, CA 94121.
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Current Author Addresses: Drs. O'Kelly, Massie, Tubau and Szlachcic: Veterans Administration Medical Center (111C), 4150 Clement Street, San Francisco, CA 94121.
- © 1989 American College of Physicians
