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Brain Amyloid and Alzheimer Disease
- Harry V. Vinters, MD;
- Bruce L. Miller, MD; and
- William M. Pardridge, MD
Abstract
Clinicopathologic features of Alzheimer disease, the commonest cause of presenile or senile dementia, are presented. Several of the microscopic brain lesions found in patients with this dementia share the staining properties of amyloid and at least two of these lesions (senile plaque cores and amyloid angiopathy) are biochemically identical. Theories pertinent to the origins of brain amyloid and its role in the pathogenesis of Alzheimer disease are discussed in relation to theories of the cause of this dementia. Possible treatments for Alzheimer disease developed from our knowledge of brain amyloid processing and biochemistry are considered.
Article and Author Information
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An edited summary of an Interdepartmental Conference arranged by the Department of Medicine of the UCLA School of Medicine, Los Angeles, California. William M. Pardridge, MD, is Director of Conferences. Authors who wish to cite a section of the conference and specifically indicate its author can use this example for the form of reference:
Miller BL. Clinical aspects of Alzheimer disease, pp 41-44.
In: Vinters HV, moderator. Brain amyloid and Alzheimer disease. Ann Intern Med. 1988;109:41-54.
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Grant Support: in part by grants from the State of California Department of Health Services, the Alzheimer's Disease and Related Disorders Association, and the John Douglas French Foundation for Alzheimer's Disease; a UCLA Biomedical Research Support grant; grant #850 G1-1 from the American Heart Association, Greater Los Angeles Affiliate; and a Physician Scientist Award K11 Ag 00284-12 from the National Institute of Aging to Dr. Miller. Dr. Vinters is the recipient of a John Douglas French Foundation and Wilson Foundation Fellowship.
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Requests for Reprints: Harry V. Vinters, MD, Department of Pathology/Neuropathology, UCLA School of Medicine, Los Angeles, CA 90024.
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Current Author Addresses: Drs. Vinters and Pardridge: UCLA School of Medicine, Los Angeles, California.
Dr. Miller: Harbor-UCLA Medical Center, Torrance, California.
- © 1988 American College of Physicians
