RSS Feeds
Somatostatin Treatment for Cryptosporidial Diarrhea in a Patient with the Acquired Immunodeficiency Syndrome (AIDS)
- DEBORAH J. COOK, M.D.;
- JOHN G. KELTON, M.D.;
- ANDRZEJ M. STANISZ, M.D.; and
- STEPHEN M. COLLINS, M.D.
Excerpt
In healthy persons, the coccidioidal protozoan, Cryptosporidium, can inhabit the microvillous border of intestinal epithelial cells and cause an acute self-limited diarrhea. In contrast, the protozoan can cause chronic severe secretory diarrhea in immunosuppressed patients ( 1 ).
Somatostatin has controlled diarrhea in patients with Zollinger-Ellison syndrome (2), Werner-Morrison syndrome (3-5) and the carcinoid syndrome (6). We administered somatostatin analogue (SMS-201-995,, Sandoz Pharmaceuticals, , , Dorval, Quebec) to a patient with the acquired immunodeficiency syndrome (AIDS) who was colonized with cryptosporidia and had diarrhea that was refractory to conventional medical therapy.
A 24-year-old heterosexual man with a congenital bicuspid
This 100-word excerpt has been provided in the absence of an abstract.
Article and Author Information
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▸Requests for reprints should be addressed to Stephen M. Collins, MD.; Room 3N5C, McMaster University Medical Centre, 1200 Main Street West; Hamilton, Ontario, L8N 325, Canada.
