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Humoral Hypercalcemia of Malignancy
- WILLIAM J. BURTIS, M.D., Ph.D.;
- TERENCE L. WU, B.S.;
- KARL L. INSOGNA, M.D.; and
- ANDREW F. STEWART, M.D.
- The West Haven VA Medical Center West Haven; and Yale University School of Medicine; New Haven, Connecticut
Excerpt
At the Annual Meeting of the American Society for Bone and Mineral Research last June, three groups announced the isolation and amino-acid sequencing of a protein that appears to be responsible for humoral hypercalcemia of malignancy (HHM) (1-4). Isolation of the protein, the cloning of the cDNA that encodes it and the resultant elucidation of the full-length amino-acid sequence of the HHM-factor (5, 6) cap years of steady progress in this field and have implications that extend beyond the syndrome of humoral hypercalcemia of malignancy. It is timely to review the clinical syndrome as well as its history and pathophysiology,
Acknowledgments
ACKNOWLEDGMENTS: grant support: in part by the Veterans Administration, West Haven, Connecticut, and the National Institutes of Health grant AR 30102.
