Syndromes of Acute Nonlymphocytic Leukemia
Abstract
The marriage of cytogenetics and molecular biology has resulted in major advances in our understanding of acute nonlymphocytic leukemia. These technologies reveal a number of clearly recognizable syndromes of acute nonlymphocytic leukemia. This review describes the salient features of several of these syndromes: acute myelomonocytic leukemia with abnormal eosinophils; acute nonlymphocytic leukemia with 11q abnormalities [biphenotypic leukemia with t(4;11); and acute monocytic leukemia with t(9;11)]; acute nonlymphocytic leukemia with t(8;21); acute promyelocytic leukemia; acute nonlymphocytic leukemia with normal or elevated platelet counts and rearranged 3q21 and 3q26; and acute nonlymphocytic leukemia with increased basophils and t(6;9). The pathogenesis of therapy-related leukemias is discussed also.
- bone marrow
- chromosome abnormalities
- chromosome fragile sites
- histocytochemistry
- karyotyping
- leukemia, megakaryoblastic
- leukemia, monocytic
- leukemia, myeloblastic
- leukemia, myelocytic
- leukemia, radiation-induced
- molecular biology
- myelofibrosis
- myeloperoxidase
- oncogenes
- acute nonlymphocytic leukemias
- gene translocation
- leukemia, promyelocytic
- morphology
- bone marrow
- chromosome abnormalities
- chromosome fragile sites
- histocytochemistry
- karyotyping
- leukemia, megakaryoblastic
- leukemia, monocytic
- leukemia, myeloblastic
- leukemia, myelocytic
- leukemia, radiation-induced
- molecular biology
- myelofibrosis
- myeloperoxidase
- oncogenes
- acute nonlymphocytic leukemias
- gene translocation
- leukemia, promyelocytic
- morphology
Article and Author Information
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▸From the Division of Hematology/Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, California.
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Grant support: in part by grants CA 26038, CA 32737, CA 33936, and CA30512 from the National Institutes of Health; The Dr. Murray Geisler Memorial Leukemia Fund; and The Louis Fagin Leukemia Research Foundation. Dr. Koeffler is a member of the Jonsson Comprehensive Cancer Center and has a Career Development Award from the National Institutes of Health.
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▸Requests for reprints should be addressed to Dr. H. Phillip Koeffler: Division of Hematology/Oncology, UCLA School of Medicine, Factor Building 11-240; Los Angeles, CA 90024.
- ©1987 American College of Physicians
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