Salsalate and Minimal-Change Nephrotic Syndrome

Excerpt

To the editor: Acute interstitial nephritis and minimalchange glomerulopathy has been reported as adverse reactions with most of the nonsteroidal antiinflammatory drugs (1-3), although isolated nephrotic syndrome secondary to minimalchange glomerulopathy has been infrequently attributed to these kinds of drugs (4). However, the syndrome has never been associated with the nonsteroidal antiinflammatory agent, salsalate, as it is herein reported.

A 76-year-old man was hospitalized with a clinical and biologic nephrotic syndrome. Major biochemical abnormalities included a serum albumin level of 1.63 gm/dL and proteinuria, 11 g/24-h urine sample. Moderate renal insufficiency with a serum creatinine level of 2.6 mg/dL was