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Angioimmunoblastic Lymphadenopathy, Immunoblastic Lymphoma, and False-Positive Seroconversion for Human Immunodeficiency Virus
- DIANA NUNLEY, M.D.;
- TAMARA MUSGRAVE, M.D.;
- STEVEN L. BERK, M.D.; and
- J. KELLY SMITH, M.D.
- East Tennessee State University Quillen-Dishner College of Medicine, and Veterans Administration Medical Center; Johnson City, TN
Excerpt
To the editor: Angioimmunoblastic lymphadenopathy, a rare, acquired disorder of unknown cause, shares certain clinical characteristics with the acquired immunodeficiency syndrome (AIDS). We report the case of a patient who had a clinicopathologic presentation of angioimmunoblastic lymphadenopathy with evolution to immunoblastic lymphoma who also had concomitant HIV false-positivity by enzyme-linked immunosorbent assay (ELISA) and Western blot testing. This finding contrasts those of two previous reports that described patients who had clinical and laboratory features suggestive of AIDS, and lymph node biopsy specimens that showed angioimmunoblastic lymphadenopathy (1). The finding is of further interest in light of the reports of B-cell
Acknowledgments
ACKNOWLEDGMENTS: The authors thank Drs. Howard Strieker and Alfred D. Steinberg of the National Institutes of Health for assistance in competitive ELISA testing and for helpful discussion of this case.
