RSS Feeds
Developmental Therapeutics and the Acquired Immunodeficiency Syndrome
- VINCENT T. DEVITA, Jr., M.D.;
- SAMUEL BRODER, M. D.;
- ANTHONY S. FAUCI, M.D.;
- JOSEPH A. KOVACS, M.D.; and
- BRUCE A. CHABNER, M.D.
Abstract
Patients with the acquired immunodeficiency syndrome (AIDS) die of overwhelming infections as a consequence of the destruction of the T4 subset of lymphocytes. Approaches to the treatment of AIDS have involved attempts to reestablish immune competence as well as treat opportunistic infections. The discovery of the human T-lymphotropic virus type III, which causes AIDS, has provided a specific target for screening antiviral drugs. There are many potential screening targets, from surface-binding proteins to viral integration and assembly, but most of the recent efforts have been aimed at developing drugs to inhibit the unique viral DNA polymerase (reverse transcriptase). The early studies with 3′-azido-3-deoxythymidine (AZT) have provided encouraging results.
- acquired immunodeficiency syndrome
- AIDS-related complex
- antiviral agents
- 3′-azido-3′-deoxythymidine
- bone marrow transplantation
- Candida
- Cryptococcus
- neoformans
- cytomegalovirus
- DHPG
- 2′,3′-dideoxyadenosine
- 2′,3′-dideoxycytidine
- dideoxynucleosides
- HTLV-III
- human immunodeficiency virus
- immunocompetence
- interferon type I
- interleukin 2
- Kaposi sarcoma
- Mycobacterium avium
- opportunistic infections
- pentamidine isethionate
- Pneumocystis carinii pneumonia
- pyrimethamine
- reverse transcriptase
- ribavirin
- sulfamethoxazole
- suramin syngeneic lymphocyte transfusion
- thymidine kinase
- toxoplasmosis
- trimethoprim
- trimetrexate
- virus replication
Article and Author Information
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▸An edited summary of a Combined Clinical Staff Conference held 20 February 1986 at the Amphitheater, Building 10, Bethesda, Maryland, and sponsored by the National Institutes of Health, U. S. Department of Health and Human Services.
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▸Authors who wish to cite a section of the conference and specifically cite its author can use this example for the form of reference:
BRODER S. Identification of therapies against the retroviruses, pp 569-74. In: DEVITA VT JR, moderator. Developmental therapeutics and the acquired immunodeficiency syndrome. Ann Intern Med. 1987;106:568-71.
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▸Requests for reprints should be addressed to Wendy Schubert, Sc.M.; Clinical Center Communications, Clinical Center, National Institutes of Health, Building 10, Room 1C255; Bethesda, MD 20892.
