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Immune Interventions in Disease
- JOHN L. FAHEY, M.D.;
- GREGORY SARNA, M.D.;
- ROBERT P. GALE, M.D., Ph.D.; and
- ROBERT SEEGER, M.D.
Abstract
Three therapeutic areas of clinical immunology that have seen active development recently are immunopharmacology of immunosuppressive drugs; clinical use of the alpha-, beta-, and gamma-interferons and interleukin-2; and monoclonal antibody applications in marrow transplantation and antitumor therapy. Understanding of the immune regulatory systems and of the soluble factors that convey information between immune and related cells (for example, lymphokines and cytokines and their receptors) has improved substantially. New information about established immunosuppressive drugs and the introduction of new drugs are providing new opportunities for effective treatment of autoimmune diseases and improved effectiveness of organ transplantation. Clinical trials are evaluating the use of interleukin-2 in immunodeficiency disorders and neoplastic disease. Monoclonal antibodies, which have been successfully applied to diagnostic procedures, have been shown to be useful for therapeutic applications in marrow transplantation and antitumor treatment.
- allergy and immunology
- acquired immunodeficiency syndrome
- antineoplastic agents
- autoimmune diseases
- azathioprine
- bone marrow
- cyclophosphamide
- cyclosporins
- cytokines
- graft rejection
- graft-versus-host disease
- graft versus leukemia
- immunosuppressive agents
- interferon type I
- interferon type II
- interleukin-2
- lymphokines
- monoclonal antibodies
- neuroblastoma
- transplantation, autologous
- transplantation, homologous
Article and Author Information
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▸An edited summary of an Interdepartmental Conference arranged by the Department of Medicine of the UCLA School of Medicine, Los Angeles, California. William M. Pardridge, M.D., Professor of Medicine, is Director of Conferences.
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▸Authors who wish to cite a section of the conference and specifically indicate its author can use this example for the form of reference:
SARNA G. Interferons and interleukin-2 as therapy for malignancy and the acquired immunodeficiency syndrome, pp 260-3. In: FAHEY JL, moderator. Immune interventions in disease. Ann Intern Med. 1987;106:257-74.
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Annette V. Terzian, UCLA School of Medicine, provided editorial assistance.
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Grant support: by grants CA 12800, AI 15332, CA 32731, CA 16042, and CA 09120 from the U.S. Public Health Service and by a grant from the Concern Foundation of Los Angeles.
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▸ Requests for reprints should be addressed to John L. Fahey, M.D.; Center for Interdisciplinary Research in Immunology and Disease, and the Department of Microbiology and Immunology, UCLA School of Medicine, 12-262 Factor Building; Los Angeles, CA 90024.
- ©1987 American College of Physicians
