Leprosy, Hypercalcemia, and Elevated Serum Calcitriol Levels

Excerpt

Increased calcitriol levels have been reported in patients who have hypercalcemia with sarcoid and other granulomatous diseases, which suggests that calcidiol 1-alpha-hydroxylase is produced extrarenally (1, 2). Granulomatous tissue from patients with sarcoid diseases has been shown subsequently to secrete an active calcitriol-like metabolite in vitro (3, 4). Hypercalcemia recently was documented in a patient with leprosy and suppressed calcitriol levels (5). We report the case of a patient who had leprosy, hypercalcemia, and elevated calcitriol levels.

A 53-year-old East-Indian woman had emigrated to the United States 4 years before hospitalization for repair of traumatic fractures of the right proximal