Immunologic Treatment of Digitalis Toxicity: A Tale of Two Prophecies

  1. VINCENT P. BUTLER, JR., M.D.; and
  2. THOMAS W. SMITH, M.D.
  1. Columbia University College of Physicians and Surgeons,
    New York, New York
  2. Brigham and Women's Hospital
    Boston, Massachusetts

    Excerpt

    If inadvertently the doses of the Foxglove should be prescribed too largely, exhibited too rapidly, or urged to too great a length, the knowledge of a remedy to counteract its results would be a desirable thing. Such a remedy may perhaps in time be discovered.

    Withering, 1785 (1)

    It seemed not out of the question that non-antigenic poisons after combination with protein would call forth antibodies capable of neutralizing their toxic effect. This idea . . . would hold out hopes for practical application.

    Landsteiner, 1945 (2)

    WITH THE RECENT approval by the Food and Drug Administration of the use

    This 100-word excerpt has been provided in the absence of an abstract.

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