Leukocytoclastic Vasculitis After High-Dose Methotrexate

Excerpt

To the editor: Leukocytoclastic vasculitis is a rare side effect of cytostatic treatment. This lesion has been seen after treatment with busulfan, hydroxyurea, and propylthiouracil (1), but it has not been seen in association with osteogenic sarcoma. We describe the case of a patient with osteogenic sarcoma who developed a leukocytoclastic vasculitis that could be ascribed to treatment with high-dose methotrexate.

A 45-year-old man developed osteogenic sarcoma in the condyle of his left femur. He was placed on a preoperative chemotherapeutic protocol using the drug schedule proposed by Rosen and colleagues (2). Briefly, this regimen consists of four weekly doses