Blood Glucose Control and Diabetic Complications

  1. PHILIP RASKIN, M. D.; and
  2. JULIO ROSENSTOCK, M.D.
  1. Dallas, Texas

    Abstract

    Two hypotheses have been advanced to explain the appearance of microvascular complications in diabetic patients with glycemic control. The genetic hypothesis suggests that the development of diabetic complications is genetically determined and independent of diabetic control, whereas the metabolic hypothesis suggests that long-term hyperglycemia causes the subsequent development of small-blood-vessel complications. We review data that either support or reject these hypotheses and suggest a third unifying hypothesis.

    Article and Author Information

    • ▸From the Department of Internal Medicine, University of Texas Health Science Center at Dallas, Southwestern Medical School; Dallas, Texas.

    • Grant support: in part by grants 1-M01-RR0063 and AM07307 from the National Institutes of Health, and a grant from the Juvenile Diabetes Foundation.

    • ▸Requests for reprints should be addressed to Philip Raskin, M.D.; Department of Internal Medicine, University of Texas Health Science Center at Dallas, 5323 Harry Hines Blvd.; Dallas, TX 75235.

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    1. Ann Intern Med August 1, 1986 vol. 105 no. 2 254-263
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