Benign Hypercalcemia and "Benign Hypocalcemia" in the Same Family
- PAUL BANNISTER, M. D., M.R.C.P.;
- PETER SHERIDAN, M.D., M.R.C.P.;
- JOHN DIBBLE, M.D.; and
- R. BRIAN PAYNE, M.D.
Excerpt
Familial benign hypercalcemia, first described in 1972 by Foley and colleagues (1), is an autosomaldominant condition characterized by asymptomatic hypercalcemiawithout hypercalciuria. Its clinical and pathogenetic features have been reviewed recently (2). We
describe results of a study in another family with benign hypercalcemia, some of whose second-generation offspring were found to have hypocalcemia.
A 51-year-old woman had cervical spondylosis and C5 root compression. Biochemical screening showed the following serum concentrations: calcium, 2. 77 mmol/L; inorganic phosphate, 1.08 mmol/L; and albumin, 44 g/L. Repeated serum calcium estimations ranged from 2.72 to 2.84 mmol/L. Serum parathyroid hormone concentrations were normal. We evaluated
This 100-word excerpt has been provided in the absence of an abstract.
Article and Author Information
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▸Requests for reprints should be addressed to Paul Bannister, M.R.C.P.; Department of Medicine, St. James's University Hospital; Leeds LS9 7TF, England.
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