Hypertension and Cyclosporine
- JACQUES J. SENNESAEL, M.D.;
- ALAIN G. DUPONT, M.D.;
- DIERIK L. VERBEELEN, M.D.;
- L. VAN HAELST, M.D., Ph.D.; and
- LEENDERT C. PAUL, M.D., Ph.D.
Excerpt
To the editor: Mild and reversible elevation of blood pressure is a common manifestation of cyclosporine toxicity in organ graft recipients (1) and patients with ocular inflammatory diseases of autoimmune origin (2). We noted severe and irreversible hypertension in a patient receiving this drug for treatment of Graves' ophthalmopathy.
A 39-year-old white woman with Graves' disease had severe hyperthyroidism and eye symptoms. Her blood pressure was 160/85 mm Hg on admission. Treatment was begun with methimazole, 50 mg/d; plasma exchange; and cyclosporine, 10 mg/kg body weight d. The dosage of cyclosporine was tapered over 1 month to a maintenance dosage
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