Tailor-Made Monoclonal Antibodies

  1. RONALD A. DePINHO, M.D.;
  2. LORI B. FELDMAN, B.S.; and
  3. MATTHEW D. SCHARFF, M.D.
  1. New York, New York
    A New York University Honors Program Lecture

    Abstract

    Monoclonal antibodies, potentially powerful diagnostic and therapeutic reagents, are having a significant impact in basic and clinical research. Some persisting problems must be solved, however, in order to realize the potential of this technology. We review the basic biology of antibody molecules and the genes that encode them, and discuss how this knowledge can be applied to make more effective monoclonal antibodies.

    Article and Author Information

    • ▸A New York University Honors Program Lecture.

    • ▸From the Department of Cell Biology and the Irvington House Institute, Albert Einstein College of Medicine; Bronx, New York.

    • Grant support: in part by grants AI10702, AI05231, and CA39828 from the National Institutes of Health; grant PCM8316150 from the National Science Foundation; and grant IM317D from the American Cancer Society. Dr. DePinho is a recipient of the Physician Scientist Award, AI00602 from the National Institutes of Health.

    • ▸Requests for reprints should be addressed to Ronald A. DePinho, M.D.; Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue; Bronx, NY 10461.

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    1. Ann Intern Med February 1, 1986 vol. 104 no. 2 225-233
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