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Immunopathogenesis of the Acquired Immunodeficiency Syndrome
Abstract
Many abnormalities of humoral and cellular immunity associated with the acquired immunodeficiency syndrome can be explained by the preferential infection of the T4 lymphocyte subset with the etiologic retrovirus. Severe alterations in specific T4 functions, such as inadequate immune responsiveness to specific antigen, result in devastating morbidity and mortality. On the basis of accumulated scientific knowledge, we outline the immunopathogenesis of this syndrome.
Article and Author Information
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▸From the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, Maryland.
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▸Requests for reprints should be addressed to Debra L. Bowen, M.D.; National Institutes of Health, Building 10, Room 11B-13; Bethesda, MD 20892.
