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Immunoglobulin G Antibodies to Lymphadenopathy-Associated Virus in Differently Treated French and Belgian Hemophiliacs
- Ch. ROUZIOUX, Ph.D.;
- F. BRUN-VEZINET, M.D.;
- A.M. COUROUCÉ, Ph.D.;
- C. GAZENGEL, M.D.;
- D. VERGOZ, M.D.;
- J. DESMYTER, M.D.;
- J. VERMYLEN, M.D.;
- C. VERMYLEN, M.D.;
- D. KLATZMANN, M.D.;
- D. GEROLDI, M.D.;
- C. BARREAU, Ph.D.;
- F. BARRÉ-SINOUSSI, Ph.D.;
- J.C. CHERMANN, Ph.D.;
- D. CHRISTOL, M.D.; and
- L. MONTAGNIER, M.D.
Abstract
Immunoglobulin G antibodies to lymphadenopathy-associated virus have been detected in two groups of French hemophiliacs and in one group of Belgian hemophiliacs, whose mode of treatment differed. Seropositivity was more frequent (58.9%) in patients heavily transfused with blood products of French and foreign origin than in less frequently transfused persons (10.3%). The Belgian group, treated only with local products, showed the lowest frequency of seropositivity (3.4%). In healthy French controls, 1 of 330 had antibody to the virus. The results indicate transmission of lymphadenopathy-associated virus via blood-derived products.
Article and Author Information
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▸From the Laboratoire Central de Virologie, Hôpital Claude Bernard; Centre National de Transfusion Sanguine; Centre d'Hémophilie, Hôpital Necker; Laboratoire d'Immunologie, Néphrologique, et Transplantation, Hôpital Pitié-Salpétrière; and Départment de Virologie, Institut Pasteur, Paris, France; Rega Institute and Faculty of Medicine, Leuven, Belgium; and Universitá di Pavia, Pavia, Italy.
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Grant support: by grants from the Pasteur Institute, French National League Against Cancer, Centre National de la Recherche Scientifique (CRNS, France), and the Belgian Fonds de la Recherche Scientifique Médicale.
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▸Requests for reprints should be addressed to Ch. Rouzioux, Ph.D.; Hôpital Claude Bernard, Laboratoire Central de Virologie, 10 avenue de la Porte d'Aubervilliers; 75019 Paris, France.
- ©1985 American College of Physicians
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