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Cancer in the Elderly: Basic Science and Clinical Aspects
- DAVID A. LIPSCHITZ, M.D., Ph.D.;
- SAMUEL GOLDSTEIN, M.D.;
- ROBERT REIS, Ph.D.;
- MARC E. WEKSLER, M.D.;
- RUBIN BRESSLER, M.D.; and
- BARBARA A. NEILAN, M.D.
Abstract
The incidence of cancer increases progressively with age. Rearrangements of genomes have been found to accompany cellular aging. These factors, in concert with age-dependent alterations in immune function and host defense, may help to explain the increased risk of malignant disease in aged persons. The clinical presentation and natural history of neoplasia are also affected by aging. This conference reviews recent developments in these areas, examines the effects of drug use in the elderly and implications for management, and discusses current information on how age may influence the response of cancer to therapy.
Article and Author Information
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▸From the Divisions of Hematology/Oncology and Gerontology, University of Arkansas for Medical Sciences, and the John L. McClellan Memorial Veterans Hospital, Little Rock, Arkansas; Division of Geriatrics and Gerontology, Cornell University School of Medicine, New York, New York; and the Department of Medicine, Arizona Health Sciences Center, University of Arizona, Tucson, Arizona.
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▸An edited transcription of Geriatric Research Education and Clinical Center Conference presented at the plenary session of the Fall meeting of the Southwest Oncology Group in Chicago, Illinois, 17-19 September 1983.
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▸Authors who wish to cite a section of this conference and specifically indicate its author can use this example for the form of reference:
BRESSLER R. Drug use in elderly patients, pp 223-5. In: LIPSCHITZ DA, moderator. Cancer in the elderly: basic science and clinical aspects. Ann Intern Med. 1985;102:218-28.
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▸Requests for reprints should be addressed to the Southwest Oncology Group, Operations Office, 5430 Fredricksberg Road; San Antonio, TX 78229.
