Registry for Angiofollicular Lymph Node Hyperplasia

Excerpt

To the editor: A registry of cases of localized and multicentric angiofollicular lymph node hyperplasia has been established at the University of Nebraska Medical Center. The localized form (Castleman's disease) is thought to be a benign process that occurs as solitary lymphoid mass in young patients (median age, 23.5 years). These patients are usually cured of the disorder by local excision of the mass.

Recently, a multicentric form of angiofollicular lymph node hyperplasia with significant patient morbidity and mortality has been reported (1, 2). Patients with the multicentric form are generally older (median age, 56 years) and frequently have constitutional