Possible Interaction Between Amiodarone and Phenytoin

Excerpt

Amiodarone, an investigational antiarrhythmic drug, has been reported to be effective in treating various cardiac tachyarrhythmias (1). Pharmacokinetic interactions with digoxin, warfarin, and class I antiarrhythmic drugs have been reported during treatment with amiodarone contrast barium enema, which showed a polypoid lesion at 15 cm; this patient refused biopsy or further diagnostic studies. The polyps seen during colonoscopy were small (< 5 mm) sessile polyps and had the gross appearance of hyperplastic polyps. Microscopic examination showed that two of the four polyps were adenomatous. Cancer of the colon in one patient was discovered on a routine sigmoidoscopy. Patient 2 had