Glomerular Lesions in the Acquired Immunodeficiency Syndrome

doi:10.1059/0003-4819-101-4-429

Glomerular Lesions in the Acquired Immunodeficiency Syndrome

Miami, Florida

Abstract

Between January 1982 and December 1983, 75 patients with the acquired immunodeficiency syndrome were identified in our hospitals: 35% used intravenous drugs, 50% had proteinuria in excess of 0. 5 g/dL, and 10% were nephrotic. Glomerular changes seen at autopsy in 36 patients included frequent mesangial lesions and deposits associated with mild asymptomatic proteinuria. Focal and segmental glomerular sclerosis was found in 5 patients and 4 of these had the nephrotic syndrome. Whereas reversible episodes of acute renal failure were not uncommon, terminal episodes of acute renal insufficiency occurred in 14 patients. The short survival of these patients may prevent the development of chronic renal failure.

Article and Author Information

▸From the Departments of Medicine and Pathology, University of Miami and Veterans Administration Medical Center; Miami, Florida.
Grant support: by MR 156905 from the Veterans Administration Medical Center and CA-34988 from the National Institutes of Health. Margaret A. Fischl, M.D., is a Teaching and Research Scholar of the American College of Physicians.
▸Requests for reprints should be addressed to Victoriano Pardo, M.D.; Department of Pathology, Veterans Administration Medical Center, 1201 Northwest 16th Street; Miami, FL 33125.