Liver Disease, Creatinine Clearance, and Aminoglycoside Nephrotoxicity

Excerpt

To the editor: Moore and associates (1) in their study of aminoglycoside nephrotoxicity conclude that a high initial calculated creatinine clearance, an elevated initial aminoglycoside level, 1 hour after administration of the drug, and the presence of liver disease were among the statistically significant factors associated with subsequent impairment of renal function. We believe there is a simple explanation for these findings, which unfortunately makes the interpretation of their work somewhat doubtful.

It should be noted that the nomogram of Chan and colleagues (2) was used to decide on the loading and maintenance doses of aminoglycosides. This nomogram compares the