Metoclopramide and Chemotherapy-Induced Emesis

Excerpt

To the editor: Benzodiazepines have been reported to be useful in the control of chemotherapy-induced emesis (1-3). Metoclopramide at doses of 2 mg/kg body weight every 2 hours is the single best agent for the control of cisplatin-induced emesis (4). We did a clinical trial to assess the usefulness of adding diazepam to a standard metoclopramide regimen for the control of cisplatin-induced emesis.

Eligible patients were receiving cisplatin at doses of 60 to 100 mg/m² body surface area as part of a combination chemotherapy regimen and had no contraindication to either metoclopramide or diazepam. Metoclopramide dosage was 2 mg/kg every