RSS Feeds
Unidentified Virus-Like Particles in the Intestine of Patients with the Acquired Immunodeficiency Syndrome
- FRANCIS W. CHANDLER, D.V.M., Ph.D.;
- ELIZABETH H. WHITE, M.S.;
- CAREY S. CALLAWAY, B.S.;
- THOMAS J. SPIRA, M.D.; and
- EDWIN P. EWING, Jr., M.D.
Excerpt
Although the cause of the acquired immunodeficiency syndrome is unknown, epidemiologic evidence shows that this syndrome is transmissible both sexually and parenterally (1). Recent serologic and virologic studies suggest a link between the syndrome and infection with a retrovirus related to the human T-cell leukemia virus (2-4).
After electron microscopic studies of lymph nodes from homosexual men with unexplained lymphadenopathy failed to show a virus-like agent (5), we systematically searched for virus-like particles in tissue samples from the intestine, salivary gland, testis, and prostate from patients who had died of the acquired immunodeficiency syndrome. These organs were studied because of
Acknowledgments
ACKNOWLEDGMENTS: The authors thank Laurel Morris for assistance in the preparation of the manuscript; Drs. Paul Szanto, P. Rosenbaum, L. Brempica, Stephen Mullins, Albert Davies, Kenneth McCarty, Jr., M. Steigerwald, John Adams, John Brazinsky, John Morrison, and Jeff Greene for providing autopsy specimens for study; Dr. Saleh Zaki for supplying control specimens; Alyne Harrison and Drs. Frederick Murphy, Bruce Evatt, James Curran, Harold Jaffe, Walter Dowdle, John Bennett, Donald Francis, and Gary Noble for reviewing the manuscript; and Frances Porcher for editorial review.
Article and Author Information
-
▸Requests for reprints should be addressed to Francis W. Chandler, D.V.M., Ph.D.; Division of Host Factors, Center for Infectious Diseases, Building 1, Room 2301, Centers for Disease Control; Atlanta, GA 30333.
