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Quinidine-lnduced Lupus Erythematosus
- STERLING G. WEST, M.D.;
- MATTHEW McMAHON, D.O.; and
- JOSEPH P. PORTANOVA, Ph.D.
Abstract
A 60-year-old white man presented with a syndrome of fever, polyarthritis, pleurisy, and lymphopenia, and had a positive antinuclear antibody test (after 5 months of quinidine therapy). Quinidine-induced antinuclear autoantibodies were of the IgM and IgG classes and were directed mainly to nuclear histones, predominantly histones H1 and H2B. Antibodies to native DNA and nonhistone nuclear antigens were not seen during the patient's clinical course. Upon withdrawal of quinidine therapy, the patient had prompt improvement of clinical symptoms followed by a gradual resolution of serologic abnormalities.
Article and Author Information
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▸From the Department of Medicine, Division of Rheumatology, Fitzsimons Army Medical Center, Aurora; and the Department of Medicine, Division of Clinical Immunology, University of Colorado Health Sciences Center, Denver, Colorado.
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The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of the Army or Department of Defense.
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▸Requests for reprints should be addressed to Sterling G. West, M.D.; Division of Rheumatology, Department of Medicine, Fitzsimons Army Medical Center; Aurora, CO 80045.
