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T-Cell Lymphoproliferative Syndrome Associated with Human T-Cell Leukemia/Lymphoma Virus
- SAMUEL BRODER, M.D.;
- PAUL A. BUNN, Jr., M.D.;
- ELAINE S. JAFFE, M.D.;
- WILLIAM BLATTNER, M.D.;
- ROBERT C. GALLO, M.D.;
- F. WONG-STAAL, Ph.D.;
- THOMAS A. WALDMANN, M.D.; and
- VINCENT T. DeVITA, Jr., M.D.
Abstract
Human T-cell leukemia/lymphoma virus is a unique family of T-cell tropic, human, type-C retroviruses. The discovery of this class of retroviruses provides the first proven link between retroviruses and cancer in humans. This virus is endemic in certain parts of the world, including the southeastern United States, and is associated with the development of adult T-cell leukemia/lymphoma, a fulminant lymphoproliferative disorder frequently accompanied by opportunistic infections and hypercalcemia. Over the last few years, major advances have been made in understanding the clinical, epidemiologic, molecular biologic, and immunologic features of this unique class of human RNA tumor viruses.
Article and Author Information
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▸An edited summary of a Combined Clinical Staff Conference held 9 December 1982 at the Clinical Center, Bethesda, Maryland, sponsored by the National Institutes of Health, U.S. Department of Health and Human Services
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▸Authors who wish to cite a section of the conference and specifically indicate its author can use this example for the form of reference:
GALLO RC. Isolation and characterization of human T-cell leukemia/lymphoma virus, pp. 549-51. In: BRODER S, moderator. T-cell lymphoproliferative syndrome associated with human T-cell leukemia/lymphoma virus. Ann Intern Med. 1984;100:543-57.
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▸Requests for reprints should be addressed to Samuel Broder, M.D.; Clinical Oncology Program, 6B-15 Building 10, National Cancer Institute; Bethesda; MD 20205.
