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Vitamin D Conversion by Sarcoid Lymph Node Homogenate
- REBECCA S. MASON, M.B., Ph.D.;
- THERESA FRANKEL, B.V.Sc., Ph.D.;
- YUK-LUEN CHAN, M.B.;
- DIANNE LISSNER; and
- SOLOMON POSEN, M.D.
Abstract
Recent studies suggest that hypercalcemia of sarcoidosis is due to high blood concentrations of calcitriol and that this compound may be synthesized at an extra-renal site. We report that sarcoid lymph node homogenate metabolized calcifediol to a substance indistinguishable from calcitriol, whereas six nonsarcoid lymph nodes failed to produce this compound.
Article and Author Information
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▸From the Endocrine Unit. Royal North Shore Hospital; St. Leonards, New South Wales, Australia.
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Grant support: The National Health and Medical Research Council of Australia, the New South Wales State Cancer Council, and the Coppleson Postgraduate Foundation of the University of Sydney.
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▸Requests for reprints should be addressed to Solomon Posen, M.D.; Endocrine Unit, Royal North Shore Hospital; St. Leonards, N.S.W., 2065, Australia.
- © 1984 American College of Physicians
