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Articles: Gregory L. Armstrong, Annemarie Wasley, Edgar P. Simard, Geraldine M. McQuillan, Wendi L. Kuhnert, and Miriam J. Alter The Prevalence of Hepatitis C Virus Infection in the United States, 1999 through 2002 Ann Intern Med 2006; 144: 705-714 [Abstract] [Full text] [PDF]

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The prevalence of hepatitis C virus infection: high in the US but higher in many other countries

Mark H. Kuniholm, Carlos del Rio, Kenrad E. Nelson   (14 June 2006)

The prevalence of hepatitis C virus infection: high in the US but higher in many other countries 14 June 2006
Mark H. Kuniholm, M.S. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, Carlos del Rio, Kenrad E. Nelson Send rapid response to journal: Re: The prevalence of hepatitis C virus infection: high in the US but higher in many other countries mkunihol{at}jhsph.edu Mark H. Kuniholm, et al.	TO THE EDITOR: We were encouraged by the recent article by Armstrong et al. (1) that reported both a decline in the overall prevalence of antibody to hepatitis C virus (anti-HCV) in the United States as well as a lower prevalence of anti-HCV among younger compared to older adults. While very good news, it is important to note that the HCV epidemic is a global health problem and the blood supplies of many developing countries are not routinely screened for HCV. In addition, programs to treat injection drug users and educate them about the dangers of needle sharing have had limited impact outside of a few countries in the industrialized world. In Russia and other countries of the former Soviet Union epidemics of hepatitis C and HIV are expanding rapidly and needle sharing among injection drug users is widely believed to be the major risk factor. We recently conducted a population-based survey in Georgia, a small country in the Caucuses region, using survey methodology not dissimilar to that used for the NHANES series of surveys (2). In a random sample of 2000 adults, we found that 6.7% were anti-HCV positive, and 8.1% had injected illicit drugs during their lifetimes. Over 85% of individuals who had injected illicit drugs had shared needles with others. While Armstrong et al. found that most HCV-infected Americans were born between 1945 and 1964, we found that most HCV-infected Georgians were born between 1974 and 1977. The United States has learned hard lessons from the now diminishing hepatitis C epidemic, and will reap the ‘bitter harvest’ for many years to come (3). Similarly, hepatitis C is poised to cause more morbidity and mortality than any other infectious disease in a number of developing countries. Fortunately, there has been some recognition of the seriousness of this global health problem, and WHO, the SOROS foundation, and governmental entities have invested considerable resources to combat this problem. However, the global epidemics of HCV and illicit drug use will continue to expand unless more effective collective interventions, including injection drug user harm reduction and hepatitis C research and care strategies, are implemented. From the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 and the Emory University School of Medicine, Atlanta, GA 30322 References (1) Armstrong GL, Wasley A, Simard EP, McQuillan GM, Kuhnert WL, Alter MJ. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med. 2006;144:705-14. (2) Stvilia K, Tsertsvadze T, Sharvadze L, Aladashvili M, del Rio C, Kuniholm MH et al. Prevalence of hepatitis C, HIV, and risk behaviors for blood-borne infections: a population-based survey of the adult population of T'bilisi, Republic of Georgia. J Urban Health. 2006;83:289-98. (3) Dienstag JL. Hepatitis C: a bitter harvest. Ann Intern Med. 2006;144:770-771. Conflict of Interest: None declared