 |
 |
|
Home |
Current Issue |
Past Issues |
In the Clinic |
ACP Journal Club |
CME |
Collections |
Audio/Video |
Mobile |
Subscribe |
Tools |
Help |
ACP Online
|
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.
SUMMARIES FOR PATIENTS
Bone Loss in Women with Anorexia Nervosa
21 November 2000 | Volume 133 Issue 10 | Page S-53
Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician.
The summary below is from the full report titled "Prevalence and Predictive Factors for Regional Osteopenia in Women with Anorexia Nervosa." It is in the 21 November 2000 issue of Annals of Internal Medicine (volume 133, pages 790-794). The authors are S Grinspoon, E Thomas, S Pitts, E Gross, D Mickley, K Miller, D Herzog, and A Klibanski.
What is the problem and what is known about it so far?
Anorexia nervosa is an eating disorder that is common among young women. Persons with anorexia nervosa are obsessed with being thin and severely limit the amount that they eat. As a result, they become undernourished. Health consequences of this serious and potentially deadly disease include osteopenia and osteoporosis. Osteopenia means that bones become less dense. When this bone thinning becomes severe, it is called osteoporosis. Persons with osteoporosis are at high risk for broken bones. Bone loss can begin after only 6 months of anorexia nervosa. Little is known, however, about the amount of bone loss at different places in the skeletons of persons with anorexia nervosa.
Why did the researchers do this particular study?
To examine the amounts of bone loss at different sites in the skeletons of women with anorexia nervosa and to determine whether any patient characteristics are associated with bone loss.
Who was studied?
The study included 130 women with anorexia nervosa who were recruited through community advertisements or by their doctors. Almost all of the women were white. They had had anorexia nervosa for an average of about 5.5 years.
How was the study done?
The researchers interviewed and examined all study patients. They also measured the density of each woman's bones at several locations in the spine and the hip by using a special x-ray test.
What did the researchers find?
Osteopenia and osteoporosis were common at all sites. Nearly half of the women had osteopenia at the hip, and 16% had osteoporosis at the hip. More than half had osteopenia at the spine, and almost a quarter had osteoporosis at the spine. Over 90% of women had abnormally low bone density at one or more sites in the skeleton. Weight was the factor most related to bone loss. The less a woman weighed, the more likely it was that she would have substantial bone loss.
What were the limitations of the study?
This study measured bone density at a single point in time. It does not tell us what happens to the bones of women with anorexia nervosa over time as the eating problem worsens or improves.
What are the implications of the study?
Bone loss is a very common problem for women with anorexia nervosa. Doctors who care for these women should be aware of this consequence of the disease.
Related articles in Annals:
This article has been cited by other articles:
|
|
 |
|
  A. D. DIVASTA and C. M. GORDON Hormone Replacement Therapy for the Adolescent Patient Ann. N.Y. Acad. Sci., June 1, 2008; 1135(1): 204 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Lawson, K. K. Miller, V. A. Mathur, M. Misra, E. Meenaghan, D. B. Herzog, and A. Klibanski Hormonal and Nutritional Effects on Cardiovascular Risk Markers in Young Women J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3089 - 3094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Misra, K. K. Miller, J. Cord, R. Prabhakaran, D. B. Herzog, M. Goldstein, D. K. Katzman, and A. Klibanski Relationships between Serum Adipokines, Insulin Levels, and Bone Density in Girls with Anorexia Nervosa J. Clin. Endocrinol. Metab., June 1, 2007; 92(6): 2046 - 2052. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Kaye Bone health and oral health J Am Dent Assoc, May 1, 2007; 138(5): 616 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Miller, E. E. Lee, E. A. Lawson, M. Misra, J. Minihan, S. K. Grinspoon, S. Gleysteen, D. Mickley, D. Herzog, and A. Klibanski Determinants of Skeletal Loss and Recovery in Anorexia Nervosa J. Clin. Endocrinol. Metab., August 1, 2006; 91(8): 2931 - 2937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fisher Treatment of Eating Disorders in Children, Adolescents, and Young Adults Pediatr. Rev., January 1, 2006; 27(1): 5 - 16. [Full Text] [PDF]
|
|
|
|
|
|
N. H. Golden, E. A. Iglesias, M. S. Jacobson, D. Carey, W. Meyer, J. Schebendach, S. Hertz, and I. R. Shenker Alendronate for the Treatment of Osteopenia in Anorexia Nervosa: A Randomized, Double-Blind, Placebo-Controlled Trial J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3179 - 3185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Miller, S. K. Grinspoon, J. Ciampa, J. Hier, D. Herzog, and A. Klibanski Medical Findings in Outpatients With Anorexia Nervosa Arch Intern Med, March 14, 2005; 165(5): 561 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Miller, K. A. Grieco, and A. Klibanski Testosterone Administration in Women with Anorexia Nervosa J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1428 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Heer, C. Mika, I. Grzella, N. Heussen, and B. Herpertz-Dahlmann Bone turnover during inpatient nutritional therapy and outpatient follow-up in patients with anorexia nervosa compared with that in healthy control subjects Am. J. Clinical Nutrition, September 1, 2004; 80(3): 774 - 781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Miller, S. Grinspoon, S. Gleysteen, K. A. Grieco, J. Ciampa, J. Breu, D. B. Herzog, and A. Klibanski Preservation of Neuroendocrine Control of Reproductive Function Despite Severe Undernutrition J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4434 - 4438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Gourlay and S. A. Brown Clinical Considerations in Premenopausal Osteoporosis Arch Intern Med, March 22, 2004; 164(6): 603 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Ronnenberg, X. Wang, H. Xing, C. Chen, D. Chen, W. Guang, A. Guang, L. Wang, L. Ryan, and X. Xu Low Preconception Body Mass Index Is Associated with Birth Outcome in a Prospective Cohort of Chinese Women J. Nutr., November 1, 2003; 133(11): 3449 - 3455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. S. Mehler Bulimia Nervosa N. Engl. J. Med., August 28, 2003; 349(9): 875 - 881. [Full Text] [PDF]
|
|
|
|
|
|
M. Misra, L. A. Soyka, K. K. Miller, D. B. Herzog, S. Grinspoon, D. de Chen, G. Neubauer, and A. Klibanski Serum Osteoprotegerin in Adolescent Girls with Anorexia Nervosa J. Clin. Endocrinol. Metab., August 1, 2003; 88(8): 3816 - 3822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Grinspoon, K. Miller, D. Herzog, D. Clemmons, and A. Klibanski Effects of Recombinant Human Insulin-Like Growth Factor (IGF)-I and Estrogen Administration on IGF-I, IGF Binding Protein (IGFBP)-2, and IGFBP-3 in Anorexia Nervosa: A Randomized-Controlled Study J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1142 - 1149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Committee on Adolescence Identifying and Treating Eating Disorders Pediatrics, January 1, 2003; 111(1): 204 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Soyka, M. Misra, A. Frenchman, K. K. Miller, S. Grinspoon, D. A. Schoenfeld, and A. Klibanski Abnormal Bone Mineral Accrual in Adolescent Girls with Anorexia Nervosa J. Clin. Endocrinol. Metab., September 1, 2002; 87(9): 4177 - 4185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Grinspoon, L. Thomas, K. Miller, D. Herzog, and A. Klibanski Effects of Recombinant Human IGF-I and Oral Contraceptive Administration on Bone Density in Anorexia Nervosa J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2883 - 2891. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K M Khan, T Liu-Ambrose, M M Sran, M C Ashe, M G Donaldson, J D Wark, and A Nattiv New criteria for female athlete triad syndrome? Br. J. Sports Med., February 1, 2002; 36(1): 10 - 13. [Full Text] [PDF]
|
|
|
|
 |
|
 P. S. Mehler Regional Osteoporosis in Anorexia Nervosa Ann Intern Med, November 6, 2001; 135(9): 843 - 844. [Full Text] [PDF]
|
|
|
|
|
|
S. Zipfel, M. J. Seibel, B. Lowe, P. J. Beumont, C. Kasperk, and W. Herzog Osteoporosis in Eating Disorders: A Follow-Up Study of Patients with Anorexia and Bulimia Nervosa J. Clin. Endocrinol. Metab., November 1, 2001; 86(11): 5227 - 5233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wartofsky Update in Endocrinology Ann Intern Med, October 16, 2001; 135(8_Part_1): 601 - 609. [Full Text] [PDF]
|
|
|
|
 |
|
 B. Burguera, L. C. Hofbauer, T. Thomas, F. Gori, G. L. Evans, S. Khosla, B. L. Riggs, and R. T. Turner Leptin Reduces Ovariectomy-Induced Bone Loss in Rats Endocrinology, August 1, 2001; 142(8): 3546 - 3553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Grinspoon, L. Thomas, K. Miller, S. Pitts, D. Herzog, and A. Klibanski Changes in regional fat redistribution and the effects of estrogen during spontaneous weight gain in women with anorexia nervosa Am. J. Clinical Nutrition, May 1, 2001; 73(5): 865 - 869. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Two High-Risk Groups for Osteoporosis Journal Watch Women's Health, December 4, 2000; 2000(1204): 11 - 11. [Full Text]
|
|
|
|
 |
|
 Two High-Risk Groups for Osteoporosis Journal Watch (General), November 24, 2000; 2000(1124): 3 - 3. [Full Text]
|
|
|
|
|
|
G. R. Mundy Secondary Osteoporosis: The Potential Relevance of Leptin and Low Body Weight Ann Intern Med, November 21, 2000; 133(10): 828 - 830. [Full Text] [PDF]
|
|
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Article
